Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner

@inproceedings{Avtanski2015HonokiolAL,
  title={Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner},
  author={Dimiter B. Avtanski and Arumugam Nagalingam and Panjamurthy Kuppusamy and Michael Y. Bonner and Jack L Arbiser and Neeraj Kumar Saxena and Dipali Sharma},
  booktitle={Oncotarget},
  year={2015}
}
Obesity greatly influences risk, progression and prognosis of breast cancer. As molecular effects of obesity are largely mediated by adipocytokine leptin, finding effective novel strategies to antagonize neoplastic effects of leptin is desirable to disrupt obesity-cancer axis. Present study is designed to test the efficacy of honokiol (HNK), a bioactive polyphenol from Magnolia grandiflora, against oncogenic actions of leptin and systematically elucidate the underlying mechanisms. Our results… CONTINUE READING

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