Honey: An immunomodulator in wound healing

@article{Majtn2014HoneyAI,
  title={Honey: An immunomodulator in wound healing},
  author={Juraj Majt{\'a}n},
  journal={Wound Repair and Regeneration},
  year={2014},
  volume={22}
}
  • J. Majtán
  • Published 2014
  • Biology, Medicine
  • Wound Repair and Regeneration
Honey is a popular natural product that is used in the treatment of burns and a broad spectrum of injuries, in particular chronic wounds. The antibacterial potential of honey has been considered the exclusive criterion for its wound healing properties. The antibacterial activity of honey has recently been fully characterized in medical‐grade honeys. Recently, the multifunctional immunomodulatory properties of honey have attracted much attention. The aim of this review is to provide closer… Expand
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References

SHOWING 1-10 OF 63 REFERENCES
Honey stimulates inflammatory cytokine production from monocytes.
TLDR
The results suggest that the effect of honey on wound healing may in part be related to the stimulation of inflammatory cytokines from monocytic cells, known to play an important role in healing and tissue repair. Expand
Immunomodulatory effects of honey cannot be distinguished from endotoxin.
TLDR
The results show that natural honeys induce interleukin-6 release from Mono Mac 6 cells as well as release of reactive oxygen species from all-trans retinoic acid (ATRA) differentiated HL-60 cells, and it is speculated that the observed in vitro immunomodulatory effects of honey might solely be explained by the endotoxin content in thenatural honeys. Expand
A 5.8‐kDa component of manuka honey stimulates immune cells via TLR4
TLDR
Findings reveal mechanisms and components involved in honey stimulation of cytokine induction and could potentially lead to the development of novel therapeutics to improve wound healing for patients with acute and chronic wounds. Expand
Re-introducing honey in the management of wounds and ulcers - theory and practice.
  • P. Molan
  • Medicine
  • Ostomy/wound management
  • 2002
TLDR
Honey is an effective broad-spectrum antibacterial agent that has no adverse effects on wound tissues and provides rapid autolytic debridement, deodorizes wounds, and stimulates the growth of wound tissues to hasten healing and start the healing process in dormant wounds. Expand
Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing
TLDR
Firm honeydew honey, which contains certain flavonoids, prevents TNF-α-induced proteolytic activity in cutaneous inflammation and provides clear evidence that honey may serve as a natural treatment for dermatological problems associated with a persistent inflammation. Expand
Stimulation of TNF-α release in monocytes by honey
TLDR
The effect of manuka, pasture and an artificial honey on macrophage function and TNF-alpha release could explain the suggested therapeutic properties of honey in promoting wound healing. Expand
Free radical production and quenching in honeys with wound healing potential.
TLDR
The ability to modulate production and quenching of free radicals may contribute to the demonstrated ability of some honeys to help in resolving the state of inflammation typifying chronic wounds. Expand
An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey.
TLDR
The major antioxidant properties in buckwheat honey derive from its phenolic constituents, which are present in relatively large amounts, which may also exert antibacterial activity, whereas its low pH and high free acid content may assist wound healing. Expand
Stimulation of TNF-alpha release in monocytes by honey.
TLDR
The effect of manuka, pasture and an artificial honey on macrophage function and TNF-alpha release could explain the suggested therapeutic properties of honey in promoting wound healing. Expand
Arabinogalactan proteins contribute to the immunostimulatory properties of New Zealand honeys
TLDR
It is proposed that the immunostimulatory properties of individual honeys relate to their particular content of LPS, apalbumins, the 5.8 kDa component and AGPs, which are particularly dependent on AGPs derived from the nectar of kanuka flowers. Expand
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