Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.

  title={Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.},
  author={Akira Watanabe and Hideki Ogiwara and Shogo Ehata and Akitake Mukasa and Shumpei Ishikawa and Daichi Maeda and Keisuke Ueki and Yasushi Ino and Tomoki Todo and Yasuhiro Yamada and Masashi Fukayama and Nobuhito Saito and Kohei Miyazono and Hiroyuki Aburatani},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 30},
Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We found decreased cell proliferation of a series of glioma cell lines by forced expression of DACH1. We then generated U87TR-Da glioma cells, where DACH1 expression could be activated… CONTINUE READING
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