Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.

  title={Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.},
  author={Sumiko Ogawa and Naoto Hirano and Norihito Sato and Toshitada Takahashi and Akira Hangaishi and Koji Tanaka and Mineo Kurokawa and Toshiyuki Tanaka and Kinuko Mitani and Yoshio Yazaki},
  volume={84 8},
Recently, it has been shown that the homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene. We report here that both alleles of the CDK4I gene were completely or partially deleted in human leukemia cells derived from both patients and established cell lines. Thirty-seven… CONTINUE READING
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