Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs

Abstract

In clinical practice, there are a number of cancer patients with clear family histories, but the patients lack mutations in known familial cancer syndrome genes. Recent advances in genomic technologies have enhanced the possibility of identifying causative genes in such cases. Two siblings, an elder sister and a younger brother, were found to have multiple… (More)

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Cite this paper

@inproceedings{Kukita2016HomozygousIO, title={Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs}, author={Yoji Kukita and Jiro Okami and Noriko Yoneda-Kato and Ikuko Nakamae and Takeshi Kawabata and Masahiko Higashiyama and Junya Kato and Ken Kodama and Kikuya Kato}, booktitle={Cold Spring Harbor molecular case studies}, year={2016} }