Homozygous human C3 deficiency. The role of C3 in antibody production, C-1s-induced vasopermeability, and cobra venom-induced passive hemolysis.

@article{Alper1976HomozygousHC,
  title={Homozygous human C3 deficiency. The role of C3 in antibody production, C-1s-induced vasopermeability, and cobra venom-induced passive hemolysis.},
  author={Chester A. Alper and Harvey R. Colten and J. H. S. Gear and Arthur R. Rabson and Fred S. Rosen},
  journal={The Journal of clinical investigation},
  year={1976},
  volume={57 1},
  pages={222-9}
}
Studies of the family of a patient with marked deficiency of the third component of complement (C3) demonstrated that the patient was homozygous for a blank allele at the C3 locus, C3-. Metabolic studies with purified radiolabeled C3 in the patient revealed a mildly elevated fractional catabolic rate and a markedly reduced synthesis rate, consistent with a lack of C3 synthesis as the patient's primary defect. There was also a mild increase in the rate of conversion of purified C3 added to her… CONTINUE READING

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References

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Showing 1-10 of 20 references

Reaction mechanism of the alternative pathway of complement activation

  • N. R. Cooper
  • Lancet .
  • 1973

Methodology in detection of human serum antibodies to Hemophilus influenzae , type b

  • D. T. Karzon
  • Hemophilus Influenzae . S . H . W . Sell and
  • 1969

Two anticom - plementary factors in cobra venom : hemolysis of guinea pig erythrocytes by one of them

  • R. A. Good M. R. Wolfson, H. Gewurz
  • J . Immunol .
  • 1969

A new concept of immunosuppression in hypersensitivity reactions and in transplantation immunity

  • R. A. Nelson
  • Surv . Ophthal .
  • 1966

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