Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.

@article{Smit1993HomozygousDO,
  title={Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.},
  author={Jaap Jan J. Smit and Alfred H Schinkel and Ronald P. J. Oude Elferink and Albert K. Groen and E. B. Wagenaar and Liesbeth Van Deemter and Carla A. A. M. Mol and Roelof Ottenhoff and N Margreth van der Lugt and Maria A Van Roon},
  journal={Cell},
  year={1993},
  volume={75 3},
  pages={451-62}
}
Two types of P-glycoprotein have been found in mammals: the drug-transporting P-glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The latter is encoded by the human MDR3 (also called MDR2) and the mouse mdr2 genes, and its tissue distribution (bile canalicular membrane of hepatocytes, B cells, heart, and muscle) suggests a specialized metabolic function. We have generated mice homozygous for a disruption of the mdr2 gene. These mice develop a liver disease that… CONTINUE READING
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