Homozygous deletions at 3p12 in breast and lung cancer

  title={Homozygous deletions at 3p12 in breast and lung cancer},
  author={Vasi Sundaresan and Grace Chung and Amanda Heppell-Parton and Jingbo Xiong and Catherine B. Grundy and Ian W. Roberts and Louise James and Anthony P. Cahn and Anthony J. Bench and J. B. Douglas and J Hsu Minna and Yoshitaka S Sekido and Michael Lerman and F. Latif and Jonas Bergh and Hua Li and Nick Lowe and Donald Ogilvie and Pamela Rabbitts},
We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule… CONTINUE READING

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Publications referenced by this paper.
Showing 1-4 of 4 references


JM Valdes, DA Tagle, FS. Collins
Nat. Acad. Sci. USA, 91, 5377 ± 5381. • 1994
View 3 Excerpts
Highly Influenced


H Aburent, Y Wang, +3 authors D. Housman
J. Hum. Genet., 55 Suppl., 269. • 1994


VJ Thon, M Khalil, JF. Cannon
Biologic. Chem., 268, 7509 ± 7513. • 1993


R Anand, J Riley, J Smith, A Markham, R. Butler
Acids Research, 18, 1951 ± 1956. • 1990
View 2 Excerpts

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