Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study.

@article{Kim2009HomozygousDO,
  title={Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study.},
  author={Miyoung Kim and Seon-Hee Yim and Nam-Sun Cho and Seong-ho Kang and Dae-hyun Ko and Bora Oh and Tae Young Kim and Hyun Jung Min and Cha Ja She and Hyoung Jin Kang and Hee Yung Shin and H Ahn and Sung Soo Yoon and Byoung Kook Kim and H R Shin and Kyu Sup Han and Han Ik Cho and Dong Soon Lee},
  journal={Cancer genetics and cytogenetics},
  year={2009},
  volume={195 1},
  pages={59-65}
}
The biological behavior of childhood B-lineage acute lymphoblastic leukemia (B-ALL) is different from that of adults. We performed a comprehensive analysis of the deletion and the methylation profile of CDKN2A (hereafter identified separately as p16 and p14, for the different proteins encoded) and CDKN2B (hereafter p15) in 91 newly diagnosed B-ALL patients (61 children, 30 adults). The prognostic significance of the profiles of these genes and the association between alterations in these genes… CONTINUE READING

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ISCN 2005: an international system for human cytogenetic nomenclature

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