Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping


CYTOGENETIC analysis has identified chromosome Ilpl3 as the smallest overlap region for deletions found in individuals with WAGR syndrome, which includes Wilms tumour (a recessive childhood nephroblastoma), anirida, genito-urinary abnormalities and mental retardation1. The underlying loci have since been resolved into an aniridia (AN2) locus at a telomeric… (More)
DOI: 10.1038/343774a0


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