Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.

@article{Boxtel2011HomozygousAH,
  title={Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.},
  author={Ruben van Boxtel and Raoul V. Kuiper and Pim W. Toonen and Sebastiaan A A C van Heesch and Roel Hermsen and Alain de Bruin and Edwin Cuppen},
  journal={The American journal of pathology},
  year={2011},
  volume={179 4},
  pages={1616-22}
}
The TP53 tumor suppressor gene is mutated in the majority of human cancers. Inactivation of p53 in a variety of animal models results in early-onset tumorigenesis, reflecting the importance of p53 as a gatekeeper tumor suppressor. We generated a mutant Tp53 allele in the rat using a target-selected mutagenesis approach. Here, we report that homozygosity for this allele results in complete loss of p53 function. Homozygous mutant rats predominantly develop sarcomas with an onset of 4 months of… CONTINUE READING

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