Homozygous Tangier disease and cardiovascular disease.

  title={Homozygous Tangier disease and cardiovascular disease.},
  author={C Serfaty-Lacrosni{\`e}re and Fernando Civeira and A Lanzberg and P Isaia and J{\"o}rg Berg and Edward Janus and Mark Philip Smith and Peter C. H. Pritchard and Jiri Frohlich and Robert S. Lees},
  volume={107 1},
Decreased levels of plasma high density lipoprotein (HDL) cholesterol have been associated with premature cardiovascular disease (CVD). Tangier disease is an autosomal co-dominant disorder in which homozygotes have a marked deficiency of HDL cholesterol and apolipoprotein (apo) A-I levels (both < 10 mg/dl), decreased low density lipoprotein (LDL) cholesterol levels (about 40% of normal), and mild hypertriglyceridemia. Homozygotes develop cholesterol ester deposition in tonsils (orange tonsils… CONTINUE READING


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