Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes.

@article{Triolo2009HomozygosityOT,
  title={Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes.},
  author={Taylor M Triolo and Erin E Baschal and Taylor K C Armstrong and Carrie S Toews and Pamela R. Fain and Marian Rewers and Liping Yu and Dongmei Miao and George S. Eisenbarth and Peter A. Gottlieb and Jennifer M. Barker},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 11},
  pages={4517-23}
}
CONTEXT Autoimmunity associated with Addison's disease (AD) can be detected by measuring 21-hydroxylase (21OH) autoantibodies. Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D. OBJECTIVE The objective of the study was to examine the effect of the MICA5.1 allele in subjects with 21OH autoantibodies on progression to AD. DESIGN Two components were used: 1) a cross… CONTINUE READING

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