Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-q44 in a segment of conserved synteny that includes the mouse beige locus (bg).

@article{Fukai1996HomozygosityMO,
  title={Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-q44 in a segment of conserved synteny that includes the mouse beige locus (bg).},
  author={Kazuyoshi Fukai and Jangsuk Oh and Mohammad Azharul Karim and Karen J. Moore and H H Kandil and Hidefumi Ito and Joachim B{\"u}rger and Richard A. Spritz},
  journal={American journal of human genetics},
  year={1996},
  volume={59 3},
  pages={620-4}
}
Chediak-Higashi syndrome (CHS) is an autosomal recessive disorder characterized by hypopigmentation or oculocutaneous albinism and severe immunologic deficiency with neutropenia and lack of natural killer (NK) cell function. Most patients die in childhood from pyogenic infections or an unusual lymphoma-like condition. A hallmark of the disorder is giant inclusion bodies seen in all granule-containing cells, including granulocytes, lymphocytes, melanocytes, mast cells, and neurons. Similar… CONTINUE READING