Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p.

@article{Tsujikawa1998HomozygosityMO,
  title={Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p.},
  author={Motokazu Tsujikawa and Hiroki Kurahashi and Tomoaki Tanaka and Masaki Okada and Shuji Yamamoto and Naoyuki Maeda and Hitoshi Watanabe and Yoshitsugu Inoue and A Kiridoshi and Kazuya Matsumoto and Yuko Ohashi and Shigeru Kinoshita and Yoshikazu Shimomura and Yusuke Nakamura and Yasuo Tano},
  journal={American journal of human genetics},
  year={1998},
  volume={63 4},
  pages={
          1073-7
        }
}
Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive disorder characterized clinically by grayish corneal deposits of amyloid and by severely impaired visual acuity. Most patients require corneal transplantation. To localize a gene responsible for GDLD, we performed linkage analysis of 10 consanguineous Japanese families with a total of 13 affected members. Homozygosity mapping provided a maximum LOD score of 9.80 at the D1S2741 marker locus on the short arm of chromosome… CONTINUE READING
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