Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity

@article{Jamra2011HomozygosityMI,
  title={Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity},
  author={Rami Abou Jamra and Sigrun Wohlfart and Markus Zweier and Steffen Uebe and Lutz Priebe and Arif B{\"u}lent Ekici and Susanne Giesebrecht and Ahmad Abboud and Mohammed Ayman Al Khateeb and Mahmoud Fakher and Saber Hamdan and Amina Ismael and Safia Muhammad and Markus M. N{\"o}then and Johannes Schumacher and Andr{\'e} Reis},
  journal={European Journal of Human Genetics},
  year={2011},
  volume={19},
  pages={1161-1166}
}
Non-specific intellectual disability of autosomal recessive inheritance (NS-ARID) represents an important fraction of severe cognitive dysfunction disorders. To date, only 10 genes have been identified, and further 24 linked-ARID loci have been reported, as well as others with suggestive linkage. To discover novel genes causing NS-ARID, we undertook genome-wide homozygosity mapping in 64 consanguineous multiplex families of Syrian descent. A total of 11 families revealed unique, significantly… 

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