Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome.

@article{Harangi2005HomozygosityFT,
  title={Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sj{\"o}gren's syndrome.},
  author={Mariann Harangi and W E Kaminski and Martin Fleck and Evelyn Orso and Margit Zeher and Emese Kiss and Zolt{\'a}n Szekanecz and Erika Zilahi and Joerg Marienhagen and Charalampos Aslanidis and Gy{\"o}rgy J R Paragh and Anne Isine Bolstad and Roland Jonsson and Gerd Schmitz},
  journal={European journal of immunology},
  year={2005},
  volume={35 1},
  pages={305-17}
}
The genes for the human ATP-binding cassette (ABC) transporter ABCA7 and the minor histocompatibility antigen HA-1 are juxtaposed in close proximity on chromosome 19p13.3. The multispan transmembrane protein ABCA7 contains an extracellular domain that is recognized by antisera from patients with Sjögren's syndrome ("Sjögren-epitope"). Recent work from our… CONTINUE READING