Homotypic vacuolar fusion mediated by t- and v-SNAREs

@article{Nichols1997HomotypicVF,
  title={Homotypic vacuolar fusion mediated by t- and v-SNAREs},
  author={Benjamin J Nichols and Christian Ungermann and Hugh R. B. Pelham and William Wickner and Albert Haas},
  journal={Nature},
  year={1997},
  volume={387},
  pages={199-202}
}
Membrane fusion is necessary both in the eukaryotic secretory pathway and for the inheritance of organelles during the cell cycle. In the secretory pathway, heterotypic fusion takes place between small transport vesicles and organelles. It requires N-ethylmaleimide-sensitive fusion protein (NSF/Sec18p), soluble NSF attachment proteins (SNAPs/Sec17p) and SNAP receptors (SNAREs). SNAREs are integral membrane proteins (v-SNAREs on vesicles, t-SNAREs on the target organelles) and are thought to… CONTINUE READING
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