Homotypic interactions protect chronic lymphocytic leukaemia cells from spontaneous death in vitro.

@article{Pettitt2001HomotypicIP,
  title={Homotypic interactions protect chronic lymphocytic leukaemia cells from spontaneous death in vitro.},
  author={Andrew R. Pettitt and Elizabeth C Moran and John C. Cawley},
  journal={Leukemia research},
  year={2001},
  volume={25 11},
  pages={1003-12}
}
Chronic lymphocytic leukaemia (CLL) cells are long-lived in vivo but undergo spontaneous apoptosis when cultured in vitro. Since CLL cells associate intimately with one another at sites of tissue involvement, we examined the hitherto unproven possibility that homotypic interactions between the malignant cells might reduce their propensity to undergo spontaneous cell death. In a series of experiments in which highly pure CLL-cell populations were cultured on a non-adherent surface, cell… CONTINUE READING

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