Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant

  title={Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant},
  author={Jennifer D. Watkins and Grant R. Campbell and Hubert Halimi and Erwann P. Loret},
  pages={83 - 83}
The HIV-1 Tat protein is a promising target to develop AIDS therapies, particularly vaccines, due to its extracellular role that protects HIV-1-infected cells from the immune system. Tat exists in two different lengths, 86 or 87 residues and 99 or 101 residues, with the long form being predominant in clinical isolates. We report here a structural study of the 99 residue Tat Eli variant using 2D liquid-state NMR, molecular modeling and circular dichroism. Tat Eli was obtained from solid-phase… CONTINUE READING

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