Homonojirimycin and N-methyl-homonojirimycin inhibit N-linked oligosaccharide processing.

@article{Zeng1997HomonojirimycinAN,
  title={Homonojirimycin and N-methyl-homonojirimycin inhibit N-linked oligosaccharide processing.},
  author={Yaowu Zeng and Yuan T Pan and Naoki Asano and Robert J. Nash and Alan D Elbein},
  journal={Glycobiology},
  year={1997},
  volume={7 2},
  pages={297-304}
}
Homonojirimycin (HNJ) and N-methylhomonojirimycin (MHNJ) were tested as inhibitors of the purified glycoprotein processing enzymes, glucosidase I and glucosidase II. MHNJ was a reasonably good inhibitor of glucosidase I (Ki = 1 x 10(-6) M) and was about three times as effective on this enzyme as was HNJ. On the other hand, HNJ inhibited glucosidase II with a Ki of about 1 x 10(-6) M, whereas MHNJ was three times less effective (Ki = 3 x 10(-5) M). However, the butyl derivative of HNJ had very… CONTINUE READING