Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells.

@article{Liskay1987HomologyRF,
  title={Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells.},
  author={R. Michael Liskay and A Letsou and J L Stachelek},
  journal={Genetics},
  year={1987},
  volume={115 1},
  pages={161-7}
}
We report experiments designed to test homology dependence for gene conversion between duplicated chromosomal sequences in cultured mammalian cells. The experimental system is such that gene conversion events not associated with reciprocal exchange are recoverable. For this study four plasmids were constructed. Each contains a different duplication of the herpes simplex virus thymidine kinase (HSV tk) gene sequence. In particular, the interacting sequences share different lengths of homology… CONTINUE READING

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