Homology of melanoma-inducing loci in the genus Xiphophorus.

@article{Schartl1990HomologyOM,
  title={Homology of melanoma-inducing loci in the genus Xiphophorus.},
  author={Manfred Schartl},
  journal={Genetics},
  year={1990},
  volume={126 4},
  pages={1083-91}
}
Several species of the genus Xiphophorus are polymorphic for specific pigment patterns. Some of these give rise to malignant melanoma following the appropriate crossings. For one of these pattern loci from the playfish Xiphophorus maculatus the melanoma-inducing gene has been cloned and found to encode a novel receptor tyrosine kinase, designated Xmrk. Using molecular probes from this gene in Southern blot analyses on single fish DNA preparations from 600 specimens of different populations of… CONTINUE READING
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