Homology of lipoprotein lipase to pancreatic lipase.

  title={Homology of lipoprotein lipase to pancreatic lipase.},
  author={C M Ben-Avram and Osnat Ben-Zeev and Terry D. Lee and K Haaga and John E Shively and J W Goers and M E Pedersen and Joseph R. Reeve and Michael C. Schotz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 12},
Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase resolved a number of peptides, five of which contained cysteine. Sequence analysis of the tryptic peptides revealed in most instances a close homology to porcine pancreatic lipase… CONTINUE READING

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