Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity.

  • David F. V. Lewis
  • Published 1999 in
    Experimental and toxicologic pathology : official…

Abstract

Molecular modelling of human cytochrome P450 (CYP) isoforms is described, based on amino acid sequence homology with a unique bacterial P450 (CYP102) of known crystal structure. It is found that for the human hepatic P450s involved in the metabolism of xenobiotics, ie. CYPIA2, CYP 1A6, CYP2B6, CYP2C9, CYP2C 19, CYP2D6, CYP2E1 and CYP3A4, there is a… (More)

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Cite this paper

@article{Lewis1999HomologyMO, title={Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity.}, author={David F. V. Lewis}, journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie}, year={1999}, volume={51 4-5}, pages={369-74} }