Homology modelling by distance geometry.

  title={Homology modelling by distance geometry.},
  author={Andr{\'a}s Asz{\'o}di and William R. Taylor},
  journal={Folding & design},
  volume={1 5},
BACKGROUND Unknown protein structures can be predicted from known structures (the scaffolds) with sequences sufficiently homologous to that of the target, based on the observation that similar sequences usually adopt the same fold. When structural equivalences between residues in the scaffold and target proteins are expressed in terms of conserved interatomic distances, the resulting 'distance geometry' representation provides an elegant mechanism for simultaneous restraint satisfaction and… CONTINUE READING

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