Homology modeling of the CG-specific DNA methyltransferase SssI and its complexes with DNA and AdoHcy.

@article{Koudan2004HomologyMO,
  title={Homology modeling of the CG-specific DNA methyltransferase SssI and its complexes with DNA and AdoHcy.},
  author={Elizaveta V Koudan and Janusz M. Bujnicki and Elizaveta S. Gromova},
  journal={Journal of biomolecular structure & dynamics},
  year={2004},
  volume={22 3},
  pages={339-45}
}
Prokaryotic DNA methyltransferase M.SssI recognizes and methylates C5 position of the cytosine residue within the CG dinucleotides in DNA. It is an excellent model for studying the mechanism of interaction between CG-specific eukaryotic methyltransferases and DNA. We have built a structural model of M.SssI in complex with the substrate DNA and its analogues as well as the cofactor analogue S-adenosyl-L-homocysteine (AdoHcy) using the previously solved structures of M.HhaI and M.HaeIII as… CONTINUE READING

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