Homology modeling of a heme protein, lignin peroxidase, from the crystal structure of cytochrome c peroxidase.

@article{Du1992HomologyMO,
  title={Homology modeling of a heme protein, lignin peroxidase, from the crystal structure of cytochrome c peroxidase.},
  author={P Du and Jack R. Collins and Gilda H. Loew},
  journal={Protein engineering},
  year={1992},
  volume={5 7},
  pages={679-91}
}
A 3-dimensional model of lignin peroxidase (LiP) was constructed based on its sequence homology with other peroxidases, particularly cytochrome c peroxidase, the only protein with a known crystal structure in the peroxidase family. The construction of initial conformations of insertions and deletions was assisted by secondary structure predictions, amphipathic helix predictions, and consideration of the specific protein environment. A succession of molecular dynamics simulations of these… CONTINUE READING