Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel.

@article{Sheng2005HomologyMI,
  title={Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel.},
  author={Jian-zhong Sheng and Aalim M Weljie and Lusia Sy and Shizhang Ling and Hans J. Vogel and Andrew P Braun},
  journal={Biophysical journal},
  year={2005},
  volume={89 5},
  pages={
          3079-92
        }
}
Activation of BK(Ca) channels by direct Ca(2+) binding and membrane depolarization occur via independent and additive molecular processes. The "calcium bowl" domain is critically involved in Ca(2+)-dependent gating, and we have hypothesized that a sequence within this domain may resemble an EF hand motif. Using a homology modeling strategy, it was observed that a single Ca(2+) ion may be coordinated by the oxygen-containing side chains of residues within the calcium bowl (i.e., (912… CONTINUE READING

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