Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction

@article{Shim2003HomologyMO,
  title={Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction},
  author={Joong-Youn Shim and William J. Welsh and Allyn C. Howlett},
  journal={Peptide Science},
  year={2003},
  volume={71}
}
Association of cannabimimetic compounds such as cannabinoids, aminoalkylindoles (AAIs), and arachidonylethanolamide (anandamide) with the brain cannabinoid (CB1) receptor activates G‐proteins and relays signals to regulate neuronal functions. A CB1 receptor homology model was constructed using the published x‐ray crystal structure of bovine rhodopsin (Palczewski et al., Science, 2000 , Vol. 289, pp. 739–745) in the conformation most likely to represent the “high‐affinity” state for agonist… 

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