Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles

@inproceedings{Marotta2013HomologymediatedEA,
  title={Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles},
  author={Michael Marotta and Xiongfong Chen and Takaaki Watanabe and Pieter Wiebren Faber and Scott J. Diede and Stephen J. Tapscott and Raymond R. Tubbs and Anna A. Kondratova and Robert Stephens and Hisashi Tanaka},
  booktitle={Nucleic acids research},
  year={2013}
}
Breakage-fusion-bridge (BFB) cycle is a series of chromosome breaks and duplications that could lead to the increased copy number of a genomic segment (gene amplification). A critical step of BFB cycles leading to gene amplification is a palindromic fusion of sister chromatids following the rupture of a dicentric chromosome during mitosis. It is currently unknown how sister chromatid fusion is produced from a mitotic break. To delineate the process, we took an integrated genomic, cytogenetic… CONTINUE READING