Homologous type II collagen induces chronic and progressive arthritis in mice.

@article{Holmdahl1986HomologousTI,
  title={Homologous type II collagen induces chronic and progressive arthritis in mice.},
  author={Rikard Holmdahl and Liselotte Jansson and E. -L. Larsson and Kristofer Rubin and Lars Klareskog},
  journal={Arthritis and rheumatism},
  year={1986},
  volume={29 1},
  pages={106-13}
}
Native mouse type II collagen was used for immunization of DBA/1 mice. Arthritis developed exclusively in male animals and was characterized by a variable and delayed onset, a slow and progressive development, and frequent exacerbations of disease in several joints including those that were previously affected. Titers of anti-type II collagen autoantibodies… CONTINUE READING