Homologous recombinational repair vis-à-vis chlorambucil resistance in chronic lymphocytic leukemia.

  title={Homologous recombinational repair vis-{\`a}-vis chlorambucil resistance in chronic lymphocytic leukemia.},
  author={Vanessa E Bello and Raquel S. Aloyz and Garyfallia Christodoulopoulos and Lawrence Panasci},
  journal={Biochemical pharmacology},
  volume={63 9},
The objective of this study was to further define the role of homologous recombinational repair (HRR) in resistance to the nitrogen mustards in B-cell chronic lymphocytic leukemia (B-CLL). We have demonstrated previously that increased chlorambucil (CLB)-induced HsRad51 nuclear foci formation correlated with a CLB-resistant phenotype in B-CLL lymphocytes. In this report, we measured the protein levels of HsRad51 and Xrcc3 (an HsRad51 paralog) and correlated them with the in vitro CLB… CONTINUE READING


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