Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange.

@article{Lambert2010HomologousRR,
  title={Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange.},
  author={Sarah A. E. Lambert and Ken'Ichi Mizuno and Jo{\"e}l Blaisonneau and Sylvain Martineau and Roland Chanet and Karine Fr{\'e}on and J. M. Murray and Antony M Carr and Giuseppe Baldacci},
  journal={Molecular cell},
  year={2010},
  volume={39 3},
  pages={346-59}
}
Template switching induced by stalled replication forks has recently been proposed to underlie complex genomic rearrangements. However, the resulting models are not supported by robust physical evidence. Here, we analyzed replication and recombination intermediates in a well-defined fission yeast system that blocks replication forks. We show that, in response to fork arrest, chromosomal rearrangements result from Rad52-dependent nascent strand template exchange occurring during fork restart… CONTINUE READING

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