Homologous recombination research is heating up and ready for therapy.

Abstract

A report in PNAS suggests that mild hyperthermia can inhibit the process of homologous recombination (HR) and degrade the BRCA2 protein (1). Cellular hyperthermia, up to temperatures of 41 °C to 43 °C, has long been known to be a potent radiosensitizer of proliferating cells, providing the opportunity to enhance the tumoricidal effects of therapeutical… (More)
DOI: 10.1073/pnas.1106456108

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