Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions

@article{Sakamoto2007HomologousRR,
  title={Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions},
  author={Shuichi Sakamoto and Kenta Iijima and Daisuke Mochizuki and Kenji Nakamura and Keisuke Teshigawara and Junya Kobayashi and Shinya Matsuura and Hiroshi Tauchi and Kenshi Komatsu},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6002-6009}
}
The proteins responsible for radiation sensitive disorders, NBS1, kinase ataxia-telangiectasia-(A-T)-mutated (ATM) and MRE11, interact through the C-terminus of NBS1 in response to the generation of DNA double-strand breaks (DSBs) and are all implicated in checkpoint regulation and DSB repair, such as homologous recombination (HR). We measured the ability of several NBS1 mutant clones and A-T cells to regulate HR repair using the DR-GFP or SCneo systems. ATM deficiency did not reduce the HR… CONTINUE READING
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