Homologous recombination prevents methylation-induced toxicity in Escherichia coli

@article{Nowosielska2006HomologousRP,
  title={Homologous recombination prevents methylation-induced toxicity in Escherichia coli},
  author={Anetta Nowosielska and Stephen J. Smith and Bevin P. Engelward and M. G. Marinus},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={2258 - 2268}
}
Methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and methyl methane sulfonate (MMS) produce a wide variety of N- and O-methylated bases in DNA, some of which can block replication fork progression. Homologous recombination is a mechanism by which chromosome replication can proceed despite the presence of lesions. The two major recombination pathways, RecBCD and RecFOR, which repair double-strand breaks (DSBs) and single-strand gaps respectively, are needed to protect… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…