Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria

@article{Dahal2017HomologousRR,
  title={Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria},
  author={Sumedha Dahal and Shubham Dubey and S. Raghavan},
  journal={Cellular and Molecular Life Sciences},
  year={2017},
  volume={75},
  pages={1641-1655}
}
Mitochondrial DNA is frequently exposed to oxidative damage, as compared to nuclear DNA. Previously, we have shown that while microhomology-mediated end joining can account for DNA deletions in mitochondria, classical nonhomologous DNA end joining, the predominant double-strand break (DSB) repair pathway in nucleus, is undetectable. In the present study, we investigated the presence of homologous recombination (HR) in mitochondria to maintain its genomic integrity. Biochemical studies revealed… Expand
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