Homologous recombination is required for AAV-mediated gene targeting

Abstract

High frequencies of gene targeting can be achieved by infection of mammalian cells with recombinant adeno-associated virus (rAAV) vectors [D. W. Russell and R. K. Hirata (1998) Nature Genet., 18, 325-330; D. W. Russell and R. K. Hirata (2000) J. Virol., 74, 4612-4620; R. Hirata et al. (2002) Nat. Biotechnol., 20, 735-738], but the mechanism of targeting is… (More)

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@article{Vasileva2006HomologousRI, title={Homologous recombination is required for AAV-mediated gene targeting}, author={Ana Vasileva and Ralph Michael Linden and Rolf Jessberger}, journal={Nucleic Acids Research}, year={2006}, volume={34}, pages={3345 - 3360} }