Homologous recombination as an evolutionary force in the avian influenza A virus.

@article{He2009HomologousRA,
  title={Homologous recombination as an evolutionary force in the avian influenza A virus.},
  author={Chengqiang He and Zhi-xun Xie and Guan-Zhu Han and Jian-bao Dong and Dong Wang and Jia-bo Liu and Le-Yuan Ma and Xiao-fei Tang and Xi-ping Liu and Yao-shan Pang and Guo-Rong Li},
  journal={Molecular biology and evolution},
  year={2009},
  volume={26 1},
  pages={177-87}
}
Avian influenza A viruses (AIVs), including the H5N1, H9N2, and H7N7 subtypes, have been directly transmitted to humans, raising concerns over the possibility of a new influenza pandemic. To prevent a future avian influenza pandemic, it is very important to fully understand the molecular basis driving the change in AIV virulence and host tropism. Although virulent variants of other viruses have been generated by homologous recombination, the occurrence of homologous recombination within AIV… CONTINUE READING

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