Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases

@article{Ouyang2008HomologousRA,
  title={Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases},
  author={Karen J. Ouyang and Leslie L. Woo and Nathan A. Ellis},
  journal={Mechanisms of Ageing and Development},
  year={2008},
  volume={129},
  pages={425-440}
}
Homologous recombination (HR) is a genetic mechanism in somatic cells that repairs DNA double-strand breaks and restores productive DNA synthesis following disruption of replication forks. Although HR is indispensable for maintaining genome integrity, it must be tightly regulated to avoid harmful outcomes. HR-associated genomic instabilities arise in three human genetic disorders, Bloom syndrome (BS), Werner syndrome (WS), and Rothmund-Thomson syndrome (RTS), which are caused by defects in… Expand
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TLDR
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