Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.

@article{Nemoto2010HomologousPR,
  title={Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.},
  author={Takayuki K. Nemoto and Shinya Satoh and Toyoaki Maruta and Tasuku Kanai and Norie Yoshikawa and Satoshi Miyazaki and Toshihiko Yanagita and Akihiko Wada},
  journal={Neuropharmacology},
  year={2010},
  volume={58 7},
  pages={1097-108}
}
In cultured bovine adrenal chromaffin cells, approximately 24 h-treatment with insulin-like growth factor-I (IGF-I) decreased cell surface (125)I-IGF-I binding capacity and IGF-I receptor protein level by approximately 64% (EC(50) = 5.0 nM; t(1/2) = approximately 7 h). IGF-I-induced IGF-I receptor decrease was abolished by LY294002 (phosphoinositide 3-kinase inhibitor) and partially attenuated by rapamycin (an inhibitor of mammalian target of rapamycin [mTOR]). SB216763 (an inhibitor of… CONTINUE READING
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