Homologous desensitization of the D1 dopamine receptor.

  title={Homologous desensitization of the D1 dopamine receptor.},
  author={Anthony J. Balmforth and Philip Warburton and Stephen G. Ball},
  journal={Journal of neurochemistry},
  volume={55 6},
Preincubation of D384 cells, derived from the human astrocytoma cell line G-CCM, with dopamine resulted in a time-dependent attenuation of cyclic AMP responsiveness to subsequent dopamine stimulation. This effect was agonist specific because the prostaglandin E1 (PGE1) stimulation of cyclic AMP of similarly treated cells remained unchanged. The attenuation by dopamine was concentration dependent with a maximum observed at 100 microM. A comparison of dopamine concentration-response curves of… CONTINUE READING
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