Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway.

@article{Kagaya1993HomologousDO,
  title={Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway.},
  author={Ariyuki Kagaya and Masahiko Mikuni and Shogo Muraoka and Keiji Saitoh and Tsuguhiro Ogawa and Hidenori Shinno and Shigeto Yamawaki and Kumiko Takahashi},
  journal={Journal of neurochemistry},
  year={1993},
  volume={61 3},
  pages={1050-6}
}
Serotonin 5-HT2 receptor-mediated intracellular Ca2+ mobilization was investigated in rat glioma C6BU-1 cells. The receptors became desensitized after previous exposure to 5-HT in a time- and concentration-dependent manner. The desensitization of 5-HT2 receptor-mediated intracellular signaling appeared to be homologous because previous exposure to 5-HT did not alter the response to other transmitters such as thrombin or isoproterenol and because previous exposure to thrombin or isoproterenol… CONTINUE READING

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