Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.

@article{Okwu1992HomologousDO,
  title={Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.},
  author={A K Okwu and Michael E. Ullian and Perry V. Halushka},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={262 1},
  pages={238-45}
}
Desensitization of platelet thromboxane (TX)A2/prostaglandin (PG)H2 receptors was induced by incubating platelet-rich plasma with the stable PGH2 analog 11 alpha,9 alpha-(epoxymethano)prosta-5Z,13E-dienoic acid (U46619) (1 microM). Iloprost, a stable prostacyclin analog, was included in the incubation to prevent platelet activation. The TXA2 mimetic, [1S-1… CONTINUE READING