Homologous and nonhomologous retroviral recombinations are both involved in the transfer by infectious particles of defective avian leukosis virus-derived transcomplementing genomes.

@article{Girod1996HomologousAN,
  title={Homologous and nonhomologous retroviral recombinations are both involved in the transfer by infectious particles of defective avian leukosis virus-derived transcomplementing genomes.},
  author={Anne Girod and Andreas Drynda and Francois Loic Cosset and G{\'e}rard Verdier and Corinne Ronfort},
  journal={Journal of virology},
  year={1996},
  volume={70 8},
  pages={5651-7}
}
We previously described avian leukosis virus-based packaging cell lines that produce stocks of retroviral vectors in which replication-competent viruses were not detectable. However, following infection of target cells with these retroviral stocks, we recently obtained colonies resulting from the transmission of recombinant genomes. Here, we have analyzed their genetic structure and shown that (i) each of them results from recombination between the packaging- and integration-defective… CONTINUE READING