Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres

Abstract

The t-loop structure of mammalian telomeres is thought to repress nonhomologous end joining (NHEJ) at natural chromosome ends. Telomere NHEJ occurs upon loss of TRF2, a telomeric protein implicated in t-loop formation. Here we describe a mutant allele of TRF2, TRF2DeltaB, that suppressed NHEJ but induced catastrophic deletions of telomeric DNA. The deletion… (More)
DOI: 10.1016/j.cell.2004.10.011

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