Homologies between small nuclear RNAs and LAV/HTLV-III sequences and their possible role in the cytopathic effect of the virus.

@article{Minrovits1987HomologiesBS,
  title={Homologies between small nuclear RNAs and LAV/HTLV-III sequences and their possible role in the cytopathic effect of the virus.},
  author={J{\'a}nos Min{\'a}rovits and Judit Segesdi and Zsuzsa Kov{\'a}cs and Istv{\'a}n F{\"o}ldes},
  journal={Medical hypotheses},
  year={1987},
  volume={22 1},
  pages={27-33}
}
The mechanism of action of LAV/HTLV-III resulting in a pronounced cytopathic effect is still unknown. We demonstrate that the long terminal repeat (LTR) sequence and env gene of LAV/HTLV-III contain regions of 70-80% homology and/or complementarity with regions of small nuclear (sn) RNAs U1 and U2. On this basis, we hypothesize that the cytotoxic effect of… CONTINUE READING