Homoharringtonine and omacetaxine for myeloid hematological malignancies

  title={Homoharringtonine and omacetaxine for myeloid hematological malignancies},
  author={Shuqing L{\"u} and Jianmin Wang},
  booktitle={Journal of hematology & oncology},
Homoharringtonine (HHT), a plant alkaloid with antitumor properties originally identified nearly 40 years ago, has a unique mechanism of action by preventing the initial elongation step of protein synthesis. HHT has been used widely in China for the treatment of chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Omacetaxine, a semisynthetic form of HHT, with excellent bioavailability by the subcutaneous route, has recently been approved by FDA of… CONTINUE READING
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