Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.

@article{Coon1994HomogentisicAI,
  title={Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.},
  author={Steven L. Coon and Shaban Kotob and Bruce B. Jarvis and Shaozhao Wang and W C Fuqua and Ronald M. Weiner},
  journal={Applied and environmental microbiology},
  year={1994},
  volume={60 8},
  pages={3006-10}
}
Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene expression. Previously, melA had been cloned, sequenced, and expressed in Escherichia coli; however, the reaction product of MelA had not been identified. This report identifies that product as homogentisic acid, provides evidence that the pigment is homogentisic acid-melanin (pyomelanin), and suggests that MelA is p-hydroxyphenylpyruvate hydroxylase. This is the first report… CONTINUE READING

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